Abstract Objective To design and apply a novel puncture method, named P TO P technique, and to evaluate its efficacy and safety.Method The data of patients treated with PVA in medical institution from January 2020 to December 2022 were reviewed and analyzed.The degree of pain relief and recovery from daily activities were evaluated using VAS and LA
Gains of ubiquitylation sites in highly conserved proteins in the human lineage
Abstract Background Post-translational modification of lysine residues of specific proteins by ubiquitin modulates the degradation, localization, and activity of these target proteins.Here, we identified gains of ubiquitylation sites in highly conserved regions of human proteins that occurred during human evolution.Results We analyzed human ubiquit